abstract：:Signaling co-receptors are diverse, multifunctional components of most major signaling pathways, with roles in mediating and regulating signaling in both physiological and pathophysiological circumstances. Many of these signaling co-receptors, including CD44, glypicans, neuropilins, syndecans and TssRIII/betaglycan ar...

journal_title：Cellular signalling

authors： Mythreye K,Blobe GC

更新日期：2009-11-01 00:00:00

abstract：:The interferon regulated transcription factor IRF-1 is a tumour suppressor protein that is activated in response to viral infection and cell signalling activated by double stranded DNA lesions. IRF-1 has a short half-life (t(0.5) 20-40 min) allowing rapid changes in steady state levels by modulating its rate of degrad...

journal_title：Cellular signalling

authors： Pion E,Narayan V,Eckert M,Ball KL

更新日期：2009-10-01 00:00:00

abstract：:Neuroprotective effects of alpha(2)-adrenergic receptor (AR) agonists are mediated via the alpha(2A)AR subtype, but the molecular mechanisms underlying these actions are still not elucidated. A two-hybrid screen was performed to identify new proteins that may control alpha(2)AR receptor function and trafficking. This ...

journal_title：Cellular signalling

authors： Weber B,Schaper C,Wang Y,Scholz J,Bein B

更新日期：2009-10-01 00:00:00

abstract：:Lipopolysaccharide (LPS) has been shown to up-regulate the expression of vascular cell adhesion molecule (VCAM)-1 which contributes to the occurrence of airway inflammatory diseases. Genetic analysis reveals the existence of activator protein-1 (AP-1) binding site on VCAM-1 promoter region. However, the role of AP-1 i...

journal_title：Cellular signalling

authors： Lin WN,Luo SF,Lin CC,Hsiao LD,Yang CM

更新日期：2009-09-01 00:00:00

abstract：:The striking clinical benefit of PTH in osteoporosis began a new era of skeletal anabolic agents. Several studies have been performed, new studies are emerging out and yet controversies remain on PTH anabolic action in bone. This review focuses on the molecular aspects of PTH and PTHrP signaling in light of old player...

journal_title：Cellular signalling

authors： Datta NS,Abou-Samra AB

更新日期：2009-08-01 00:00:00

abstract：:Neuro-2a (N2a) cells are derived from spontaneous neuroblastoma of mouse and capable to differentiate into neuronal-like cells. Recently, P2X7 receptor has been shown to sustain growth of human neuroblastoma cells but its role during neuronal differentiation remains unexamined.We characterized the role of P2X7 recepto...

journal_title：Cellular signalling

authors： Wu PY,Lin YC,Chang CL,Lu HT,Chin CH,Hsu TT,Chu D,Sun SH

更新日期：2009-06-01 00:00:00

abstract：:Through diametric actions, the transforming growth factor beta (TGFbeta) and Angiotensin II (AngII) play important roles in regulating various biological responses such as cell proliferation and migration. Signaling initiated by TGFbeta and AngII occurs through two structurally and functionally distinct receptor super...

journal_title：Cellular signalling

authors： Guo J,Chen H,Ho J,Mancini J,Sontag T,Laporte SA,Richard DE,Lebrun JJ

更新日期：2009-06-01 00:00:00

abstract：:Regulation of nestin gene expression is largely unknown despite that it is widely used as a progenitor cell marker. In this study, we showed that nestin expression is regulated by the thrombin-mediated EGFR transactivation in serum-deprived primary cultures of rat vascular smooth muscle cells (VSMCs). This resulted fr...

journal_title：Cellular signalling

authors： Huang YL,Shi GY,Lee H,Jiang MJ,Huang BM,Wu HL,Yang HY

更新日期：2009-06-01 00:00:00

abstract：:The protein kinase C (PKC) family is the most prominent target of tumor-promoting phorbol esters. For the PKCepsilon isozyme, different intracellular localizations and oncogenic potential in several but not all experimental systems have been reported. To obtain information about PKCepsilon-signaling, we investigated t...

journal_title：Cellular signalling

authors： Garczarczyk D,Toton E,Biedermann V,Rosivatz E,Rechfeld F,Rybczynska M,Hofmann J

更新日期：2009-05-01 00:00:00

abstract：:Cellular growth and glucose uptake are regulated by multiple signals generated by the insulin receptor. The mechanisms of individual modulation of these signals remain somewhat elusive. We investigated the role of CaMKII in insulin signalling in a rat skeletal muscle cell line, demonstrating that CaMKII modulates the ...

journal_title：Cellular signalling

authors： Illario M,Monaco S,Cavallo AL,Esposito I,Formisano P,D'Andrea L,Cipolletta E,Trimarco B,Fenzi G,Rossi G,Vitale M

更新日期：2009-05-01 00:00:00

abstract：:Adrenomedullin is a secreted peptide hormone with multiple functions. Although a number of reports have indicated that adrenomedullin may be involved in tumor progression, its mechanism of action remains obscure. In this study, we have analysed the signal transduction pathway activated by adrenomedullin in human gliom...

journal_title：Cellular signalling

authors： Ouafik L,Berenguer-Daize C,Berthois Y

更新日期：2009-04-01 00:00:00

abstract：:Embryonic stem cells (ESC) are pluripotent and could be maintained in vitro in a self-renewing state indefinitely, at the same time preserving their potential to differentiate towards more specific lineages. Despite the progress in the field, the complex network of signalling cascades involved in the maintenance of th...

journal_title：Cellular signalling

authors： Todorova MG,Fuentes E,Soria B,Nadal A,Quesada I

更新日期：2009-04-01 00:00:00

abstract：:Lithium is an anti-depressant drug that also possesses immunomodulatory functions. The anti-inflammatory effect of lithium is thought to involve activation of the transcription factor CREB, although the underlying mechanism is incompletely understood. We show here that in macrophages lithium stimulates Tpl2, a MAP kin...

journal_title：Cellular signalling

authors： Zhang M,Jin W,Zhou X,Yu J,Lee AJ,Sun SC

更新日期：2009-04-01 00:00:00

abstract：:This article has been withdrawn at the request of the Editors. The Publisher apologises for any inconvenience that this may cause. The full Elsevier Policy on Article Withdrawal can be found at http://www.elsevier.com/locate/withdrawalpolicy. ...

journal_title：Cellular signalling

authors： Genestra M

更新日期：2009-03-27 00:00:00

abstract：:Ceramide 1-phosphate (C1P) is a bioactive sphingolipid that is implicated in the regulation of cell homeostasis and the control of inflammation. It is mitogenic for fibroblasts and macrophages, and has been described as potent inhibitor of apoptosis. Using RAW 264.7 macrophages we have now discovered a new biological ...

journal_title：Cellular signalling

authors： Granado MH,Gangoiti P,Ouro A,Arana L,González M,Trueba M,Gómez-Muñoz A

更新日期：2009-03-01 00:00:00

abstract：:Microglia play a prominent role in the brain's inflammatory response to injury or infection by migrating to affected locations, secreting inflammatory molecules, and phagocytosing damaged tissue. However, because severe or chronic neuroinflammation exacerbates many neurological conditions, controlling microglia action...

journal_title：Cellular signalling

authors： Yuskaitis CJ,Jope RS

更新日期：2009-02-01 00:00:00

abstract：:Synthesis and degradation of lipids in mammalian adipocytes are tightly and coordinatedly regulated by insulin, fatty acids, reactive oxygen species and drugs. Conversely, the lipogenic or lipolytic state of adipocytes is communicated to other tissues by the secretion of soluble adipocytokines. Here we report that ins...

journal_title：Cellular signalling

authors： Müller G,Jung C,Straub J,Wied S,Kramer W

更新日期：2009-02-01 00:00:00

abstract：:Cell surface receptors for high-density lipoprotein (HDL) on hepatocytes are major partners in the regulation of cholesterol homeostasis. We have previously demonstrated on human hepatocytes that apolipoprotein A-I binding to an ectopic F(1)-ATPase stimulates the production of extracellular ADP that activates a P2Y(13...

journal_title：Cellular signalling

authors： Malaval C,Laffargue M,Barbaras R,Rolland C,Peres C,Champagne E,Perret B,Tercé F,Collet X,Martinez LO

更新日期：2009-01-01 00:00:00

abstract：:Clathrin-mediated endocytosis is a complex process regulated at many different levels. We showed previously that activation of the angiotensin type 1 receptor (AT1R), which belongs to the G protein-coupled receptor (GPCR) family, leads to c-Src-dependent tyrosine phosphorylation of beta2-adaptin, a subunit of the clat...

journal_title：Cellular signalling

authors： Zimmerman B,Simaan M,Lee MH,Luttrell LM,Laporte SA

更新日期：2009-01-01 00:00:00

abstract：:Sphingolipids were once regarded as inert structural components of cell membranes. Now these metabolites are generally believed to be important bioactive molecules that control a wide repertoire of cellular processes such as proliferation and survival of cells. Along with these ubiquitous cell functions observed in ma...

journal_title：Cellular signalling

authors： Okada T,Kajimoto T,Jahangeer S,Nakamura S

更新日期：2009-01-01 00:00:00

abstract：:Janus kinase 2 (Jak2) has a pivotal role in erythropoietin (Epo) signaling pathway, including erythrocyte differentiation and Stat5 activation. In the course of screening for critical phosphorylation of tyrosine residues in Jak2, we identified tyrosine 913 (Y(913)) as a novel and functional phosphorylation site, which...

journal_title：Cellular signalling

authors： Funakoshi-Tago M,Tago K,Kasahara T,Parganas E,Ihle JN

更新日期：2008-11-01 00:00:00

abstract：:Epidermal growth factor (EGF) signaling is critical in normal and aberrant cellular behavior. Extracellular signal-regulated kinase (ERK) mediates important downstream aspects of EGF signaling. Additionally, EGFR undergoes MEK1-dependent ERK consensus site phosphorylation in response to EGF or cytokines such as growth...

journal_title：Cellular signalling

authors： Li X,Huang Y,Jiang J,Frank SJ

更新日期：2008-11-01 00:00:00

abstract：:The transcription factor Egr-1 is encoded by an immediate early response gene and has been shown to be a key regulator in the induction of apoptosis, mitogenesis and differentiation. It is rapidly induced by different stimuli including the glycoprotein hormone erythropoietin. In this report, we analyse the role of dif...

journal_title：Cellular signalling

authors： Schulze C,Büchse T,Mikkat S,Bittorf T

更新日期：2008-10-01 00:00:00

abstract：:Glycogen synthase kinase 3beta (GSK3beta) is implicated in many biological events, including embryonic development, cell differentiation, apoptosis, and the insulin response. GSK3beta also plays a key role in the Wnt/beta-catenin pathway. The master regulator of the pigmentation microphthalmia-associated transcription...

journal_title：Cellular signalling

authors： Bellei B,Flori E,Izzo E,Maresca V,Picardo M

更新日期：2008-10-01 00:00:00

abstract：:Human ether-à-go-go-related gene (hERG or Kv11.1) encodes the rapidly activated delayed rectifier K(+) current (I(Kr)) in the human heart. Potential regulation of hERG channel by protein tyrosine kinases (PTKs) is not understood. The present study was designed to investigate whether this channel is modulated by PTKs u...

journal_title：Cellular signalling

authors： Zhang DY,Wang Y,Lau CP,Tse HF,Li GR

更新日期：2008-10-01 00:00:00

abstract：:In diverse neuronal processes ranging from neuronal survival to synaptic plasticity cyclic adenosine monophosphate (cAMP)-dependent signaling is tightly connected with the protein kinase B (PKB)/Akt pathway but the precise nature of this connection remains unknown. In the current study we investigated the effect of tw...

journal_title：Cellular signalling

authors： Nijholt IM,Dolga AM,Ostroveanu A,Luiten PG,Schmidt M,Eisel UL

更新日期：2008-10-01 00:00:00

abstract：:We found that CKD712, an S enantiomer of YS49, strongly inhibited inducible nitric oxide synthase (iNOS) and NO induction but showed a weak inhibitory effect on cyclooxygenase-2 (COX-2) and PGE(2) induction in LPS-stimulated RAW 264.7 cells. We, therefore, investigated the molecular mechanism(s) responsible for this b...

journal_title：Cellular signalling

authors： Tsoyi K,Kim HJ,Shin JS,Kim DH,Cho HJ,Lee SS,Ahn SK,Yun-Choi HS,Lee JH,Seo HG,Chang KC

更新日期：2008-10-01 00:00:00

abstract：:Both type I interferons (IFNs) and interferon regulatory factors (IRFs) are well characterized in viral infections, whereas they are far less studied in bacterially activated toll-like receptor (TLR) pathways. Here, we studied the involvement of IRF1 and IRF2 in TLR2-mediated responses. In mouse macrophages, IRF2 was ...

journal_title：Cellular signalling

authors： Liljeroos M,Vuolteenaho R,Rounioja S,Henriques-Normark B,Hallman M,Ojaniemi M

更新日期：2008-10-01 00:00:00

abstract：:Agonist stimulation of G-protein coupled receptors (GPCRs) results in the redistribution of the receptor from the cell surface into intracellular compartments through the process of endocytosis. Monitoring ligand-mediated internalization of GPCRs in living cells has become experimentally accessible by applying fluores...

journal_title：Cellular signalling

authors： Böhme I,Stichel J,Walther C,Mörl K,Beck-Sickinger AG

更新日期：2008-10-01 00:00:00

abstract：:Pancreatic fibrosis, a key feature of chronic pancreatitis and pancreatic cancer, is mediated by activated pancreatic stellate cells (PSC). Connective tissue growth factor (CTGF) has been suggested to play a major role in fibrogenesis by enhancing PSC activation after binding to alpha5beta1 integrin. Here, we have foc...

journal_title：Cellular signalling

authors： Karger A,Fitzner B,Brock P,Sparmann G,Emmrich J,Liebe S,Jaster R

更新日期：2008-10-01 00:00:00

abstract：:Both canonical Wnt/beta-catenin and TGFbeta/Smad signaling pathways coordinately regulate pattern formation during embryogenesis as well as tumor progression. Evidence of cross-talk between these two pathways has been reported. Here we demonstrated that the Activin-like kinase 4 (Alk4)/Smad2 pathway facilitates the tr...

journal_title：Cellular signalling

authors： Hirota M,Watanabe K,Hamada S,Sun Y,Strizzi L,Mancino M,Nagaoka T,Gonzales M,Seno M,Bianco C,Salomon DS

更新日期：2008-09-01 00:00:00

abstract：:Orexin-A and orexin-B orchestrate their diverse central and peripheral effects via two G-protein coupled receptors, OX1R and OX2R, which activate multiple G-proteins. In many tissues, orexins activate extracellular signal-regulated kinase (ERK(1/2)) and p38 mitogen-activated protein kinase (MAPK); however, the mechani...

journal_title：Cellular signalling

authors： Tang J,Chen J,Ramanjaneya M,Punn A,Conner AC,Randeva HS

更新日期：2008-09-01 00:00:00

abstract：:Expression of the human cytomegalovirus (HCMV)-encoded chemokine receptor homologue pUS28 in mammalian cells results in ligand-dependent and -independent changes in the activity of multiple cellular signal transduction pathways. The ligand-dependent signalling activity of pUS28 has been shown to be predominantly media...

journal_title：Cellular signalling

authors： Moepps B,Tulone C,Kern C,Minisini R,Michels G,Vatter P,Wieland T,Gierschik P

更新日期：2008-08-01 00:00:00

abstract：:Leptin, the adipocyte-secreted hormone that centrally regulates weight control, is known to function as an immunomodulatory regulator. We investigated the signaling pathway involved in IL-8 production caused by leptin in both rheumatoid arthritis synovial fibroblasts (RASF) and osteoarthritis synovial fibroblasts (OAS...

journal_title：Cellular signalling

authors： Tong KM,Shieh DC,Chen CP,Tzeng CY,Wang SP,Huang KC,Chiu YC,Fong YC,Tang CH

更新日期：2008-08-01 00:00:00

abstract：:In humans, thromboxane (TX) A(2) signals through the TPalpha and TPbeta isoforms of the TXA(2) receptor that exhibit common and distinct roles. For example, Gq/phospholipase (PL)Cbeta signaling by TPalpha is directly inhibited by the vasodilators prostacyclin and nitric oxide (NO) whereas that signaling by TPbeta is u...

journal_title：Cellular signalling

authors： Wikström K,Kavanagh DJ,Reid HM,Kinsella BT

更新日期：2008-08-01 00:00:00

abstract：:Type I cGMP-dependent protein kinases (PKGs) translocate to the nucleus to regulate gene expression in some, but not all cell types; we hypothesized that nuclear translocation of PKG may be regulated by extra-nuclear anchoring proteins. The inositol 1,4,5-triphosphate (IP(3)) receptor-associated cGMP kinase substrate ...

journal_title：Cellular signalling

authors： Casteel DE,Zhang T,Zhuang S,Pilz RB

更新日期：2008-07-01 00:00:00

abstract：:Caveolin-1 (Cav-1) is a major structural protein of caveolae and plays an important role as a negative regulator of various signaling pathways such as the transforming growth factor-beta (TGF-beta)/smad pathway. In this study, we investigated the role of cav-1 on basal and TGF-beta1-induced expression of type I procol...

journal_title：Cellular signalling

authors： Kim S,Lee Y,Seo JE,Cho KH,Chung JH

更新日期：2008-07-01 00:00:00

abstract：:Zfra is a small size 31-amino-acid C2H2 zinc finger-like protein, which is known to interact with c-Jun N-terminal kinase 1 (JNK1), WW domain-containing oxidoreductase (WWOX, FOR or WOX1), TNF receptor-associated death domain protein (TRADD) and nuclear factor kappaB (NF-kappaB) during stress response. Here, we show t...

journal_title：Cellular signalling

authors： Hsu LJ,Hong Q,Schultz L,Kuo E,Lin SR,Lee MH,Lin YS,Chang NS

更新日期：2008-07-01 00:00:00

abstract：:The immune modulator FTY720 is phosphorylated in vivo to FTY720 phosphate (FTY-P), which activates four sphingosine 1-phosphate (S1P) receptors including S1P(3). Upon activation with S1P, S1P(3) couples to G(i)- and G(q)-protein-dependent signalling pathways. Here we show that FTY-P selectively activates the S1P(3)-me...

journal_title：Cellular signalling

authors： Sensken SC,Stäubert C,Keul P,Levkau B,Schöneberg T,Gräler MH

更新日期：2008-06-01 00:00:00

abstract：:Tribbles 3 homolog (TRB3) is recently identified as a scaffold-like regulator of various signal transducers and has been implicated in several processes including insulin signaling, NF-kappaB signaling, lipid metabolism and BMP signaling. To further understand cellular mechanisms of TRB3 regulation, we performed a yea...

journal_title：Cellular signalling

authors： Zhou Y,Li L,Liu Q,Xing G,Kuai X,Sun J,Yin X,Wang J,Zhang L,He F

更新日期：2008-05-01 00:00:00